Izervay benefits and risks: how it works, who should get it, dosing schedule, and side effects
Izervay is a prescription intravitreal injection used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration. It contains avacincaptad pegol, a complement C5 inhibitor designed to slow the expansion of GA lesions that gradually damage central vision. While Izervay does not restore lost photoreceptors or “cure” GA, clinical trials show it can modestly reduce lesion...
Izumio benefits: hydrogen water science, real-world uses, dosage, and safety explained
Izumio is a branded form of hydrogen-rich water (HRW)—plain water infused with dissolved molecular hydrogen gas (H₂). Fans point to H₂’s selective antioxidant and cell-signaling effects; skeptics ask whether the levels in a bottle can really matter. This guide takes a clear, evidence-based look at what HRW like Izumio may (and may not) do, how to use it practically,...
Acetyl L Carnitine for Aging: Mitochondrial Function and Cognition
Acetyl-L-carnitine (ALCAR) sits at the crossroads of energy metabolism and neurochemistry. As we age, mitochondria—our cellular power plants—become less efficient, and brain networks grow more vulnerable to metabolic stress. ALCAR is compelling because it crosses the blood–brain barrier, donates acetyl groups for acetylcholine synthesis, and supports fatty-acid transport into mitochondria. Clinicians and researchers have explored ALCAR for decades in...
Aged Garlic Extract for Longevity: Cardiovascular and Immune Support
Aged garlic extract (AGE) has a distinct profile compared with raw garlic or garlic oil. It is produced through a long extraction and aging process that stabilizes key sulfur compounds and removes much of the pungency that limits everyday use. For midlife and older adults, AGE is studied most for cardiovascular outcomes—blood pressure, lipids, and arterial health—and for seasonal...
Akkermansia Supplements and Aging: What Supplementation Can and Cannot Do
Akkermansia muciniphila is a gut microbe that has moved from research papers into supplement bottles. Interest surged after human studies showed that pasteurized preparations could be taken safely and might nudge insulin sensitivity, cholesterol, and markers of gut barrier function. Yet the story is nuanced. Akkermansia is a mucin-degrading specialist: it lives at the mucus layer and seems to...
Alpha Ketoglutarate for Aging: Where the Science Stands
Alpha ketoglutarate (AKG) has moved from biochemistry textbooks to bottles marketed for “healthy aging.” It sits in the citric acid cycle, where cells generate energy and carbon skeletons for building proteins. Interest grew after animal studies suggested late-life AKG could compress morbidity and modestly extend lifespan, while early human work explored changes in biological age markers. Yet AKG is...
Alpha Lipoic Acid for Healthy Aging: Insulin Sensitivity and Mitochondria
Alpha lipoic acid (ALA) sits at the crossroads of glucose metabolism and mitochondrial defense. As a cofactor in mitochondrial enzyme complexes, ALA helps cells turn nutrients into usable energy. It also acts as a redox molecule—recycling antioxidants and tempering oxidative stress that mounts with age. For adults navigating midlife changes in insulin sensitivity, nerve comfort, and daily energy, ALA...
Apigenin and Luteolin for Healthy Aging: Flavones with Potential
Aging changes how our cells handle stress, energy, and inflammation. Two dietary flavones—apigenin and luteolin—sit at this crossroads. They occur naturally in foods such as chamomile, celery, parsley, thyme, and peppers. In lab studies, both compounds influence inflammatory signaling, antioxidant defenses, and cellular housekeeping processes that drift with age. Early human data are modest but directionally encouraging for sleep...
Ashwagandha for Healthy Aging: Sleep, Stress, and Cortisol
Ashwagandha (Withania somnifera) has moved from Ayurveda into mainstream conversations about healthy aging. People reach for it to steady stress, sleep better, and support resilience in midlife and beyond. The science is still maturing, yet several human trials suggest meaningful—if modest—benefits for perceived stress, cortisol regulation, and sleep quality when standardized extracts are used consistently for at least 6–8...
Astaxanthin for Aging: Skin, Eyes, and Oxidative Stress
Astaxanthin is a red-orange carotenoid best known for tinting wild salmon and microalgae. In human biology, it sits in cell membranes and quenches reactive oxygen species that accumulate with age. Early trials suggest targeted benefits for photoaged skin, visual performance under digital strain, and exercise recovery. At the same time, not every claim holds up, and dose, duration, and...
B Vitamins for Aging: B12, Folate, and B6 for Homocysteine
Homocysteine sits at a key junction of methylation and sulfur-amino-acid metabolism. When it rises, it signals friction in those pathways and, in many studies, tracks with higher vascular and cognitive risk. Vitamins B12, folate, and B6 help move homocysteine along safe routes—either remethylating it back to methionine or converting it downstream to cysteine. That biochemistry is familiar to clinicians,...
Beetroot and Nitrate Supplements for Longevity: Vascular Function and Exercise Capacity
Blood vessels age with us. As nitric oxide signaling wanes, arteries stiffen, endothelial responses dull, and blood pressure trends upward. Dietary nitrates—found in beetroot and leafy greens—offer a practical way to bolster nitric oxide through an alternate route that does not rely on stressed endothelial enzymes alone. In older adults, this can translate into smoother vascular control, modest blood...
Berberine for Healthy Aging: Glucose, Lipids, and AMPK
As we age, metabolism gets noisier: insulin signaling drifts, lipids creep up, and low-grade inflammation blunts cellular responses. Berberine—a plant alkaloid from Coptis, barberry, and related botanicals—has re-emerged as a practical tool for metabolic tune-ups. It acts on several levers at once: AMP-activated protein kinase (AMPK), gut microbiota, bile acid signaling, and LDL receptor expression. The result, in trials,...
Beta Alanine and Carnosine for Healthy Aging: Performance and Fatigue
Aging changes how muscles feel and perform. Short bursts that once felt easy—climbing stairs, carrying groceries, rising from the floor—start to sting with “burn” sooner, and recovery takes longer. Two related tools, beta alanine and carnosine, target this sensation where it starts: in the muscle cell’s handling of acid during hard work. Beta alanine raises intramuscular carnosine, a naturally...
Betaine TMG for Longevity: Methylation and Homocysteine
As we age, small biochemical drifts can compound into larger health problems. One of the best-studied signals is homocysteine, a sulfur-containing amino acid tied to methylation, vascular aging, and metabolic stress. Betaine—also called trimethylglycine (TMG)—is a simple nutrient that donates methyl groups to recycle homocysteine back to methionine. That single transfer supports healthy methylation reactions across the body, from...
Boswellia for Healthy Aging: Joint Comfort Without Reliance on NSAIDs
Modern healthy aging often means preserving the freedom to walk, climb, and stay active without leaning hard on nonsteroidal anti-inflammatory drugs (NSAIDs). Boswellia (Boswellia serrata) has emerged as a promising option for joint comfort and mobility, particularly for knees and hands. Its resin—long used in traditional medicine—contains boswellic acids that influence inflammatory signaling in a way that differs from...
