ALK Mutation Test: Lung Cancer, Targeted Therapy, and Results
An ALK mutation test looks for an abnormal change involving the ALK gene in cancer cells. In lung cancer, the important finding is usually...
APC Genetic Test: Familial Adenomatous Polyposis, Colon Cancer Risk, and Results
An APC genetic test looks for inherited harmful variants in the APC gene, the main cause of familial adenomatous polyposis. Familial adenomatous polyposis, or...
ASXL1 Mutation Test: Blood Cancer, Myeloid Neoplasm, and Results
An ASXL1 mutation test looks for acquired changes in the ASXL1 gene in blood or bone marrow cells. ASXL1 variants are found in several...
ATM Genetic Test: Breast Cancer Risk, DNA Repair, and Results
An ATM genetic test looks for an inherited harmful variant in the ATM gene, which helps cells recognize and repair damaged DNA. People with...
BAP1 Genetic Test: Melanoma, Mesothelioma, Kidney Cancer Risk, and Results
A BAP1 genetic test looks for an inherited harmful variant in the BAP1 gene, which can cause BAP1 tumor predisposition syndrome. This rare syndrome...
BCL2 Rearrangement Test: Follicular Lymphoma, Double-Hit Lymphoma, and Results
A BCL2 rearrangement test looks for a chromosome change that places the BCL2 gene under the control of a highly active partner, most often...
BCL6 Rearrangement Test: Lymphoma, Prognosis, and Results
A BCL6 rearrangement test looks for a structural change involving the BCL6 gene on chromosome 3. BCL6 normally helps germinal-center B cells grow, change...
BCR-ABL1 Test: CML, Leukemia, Philadelphia Chromosome, and Results
A BCR-ABL1 test detects or measures the fusion gene that drives chronic myeloid leukemia and a major subtype of acute lymphoblastic leukemia. The fusion...
BRAF Mutation Test: Melanoma, Colon, Thyroid, Lung Cancer, and Results
A BRAF mutation test looks for changes in the BRAF gene, which controls part of the MAPK signaling pathway that tells cells when to...
BRCA1 and BRCA2 Genetic Test: Cancer Risk, Mutations, and Results
A BRCA1 and BRCA2 genetic test looks for inherited or tumor-acquired changes in two genes that repair damaged DNA. A germline pathogenic variant can...
CALR Mutation Test: Myeloproliferative Neoplasm, Platelets, and Results
A CALR mutation test looks for acquired changes in the calreticulin gene, usually small insertions or deletions in exon 9. These mutations are major...
CCND1/IGH Fusion Test: Mantle Cell Lymphoma and Results
A CCND1/IGH fusion test looks for the chromosome translocation t(11;14)(q13;q32), which places CCND1 next to the immunoglobulin heavy-chain gene IGH. The change causes excess...
CDH1 Genetic Test: Hereditary Diffuse Gastric Cancer Risk and Results
A CDH1 genetic test looks for inherited changes in the gene that makes E-cadherin, a protein that helps epithelial cells attach to one another....
CEBPA Mutation Test: AML Prognosis, Leukemia Genetics, and Results
A CEBPA mutation test looks for changes in a gene that controls the maturation of myeloid blood cells. CEBPA mutations occur in a subset...
CHEK2 Genetic Test: Breast, Colon, Prostate Cancer Risk, and Results
A CHEK2 genetic test looks for inherited changes in a DNA-damage response gene associated most consistently with a moderate increase in female breast cancer...
Circulating Tumor DNA (ctDNA) Test: Cancer Monitoring, Mutations, and Results
A circulating tumor DNA test analyzes small fragments of cancer-derived DNA released into the bloodstream. It can identify tumor mutations without a new tissue...
Comprehensive Genomic Profiling Test: Cancer Genes, Mutations, and Results
Comprehensive genomic profiling examines many cancer-related genes and multiple types of genomic alteration in one test. It is most often used for advanced solid...
DICER1 Genetic Test: Tumor Predisposition, Cancer Risk, and Results
A DICER1 genetic test looks for inherited or mosaic changes associated with a rare tumor predisposition syndrome that can affect the lungs, kidneys, thyroid,...
DNMT3A Mutation Test: AML, Clonal Hematopoiesis, and Results
A DNMT3A mutation test looks for acquired changes in the DNMT3A gene, most often in blood or bone marrow. The result can help characterize...
EGFR Mutation Test: Lung Cancer, Targeted Therapy, and Results
An EGFR mutation test examines cancer DNA or RNA for changes in the epidermal growth factor receptor gene. In non-small-cell lung cancer, especially adenocarcinoma,...