PQQ for Longevity: Mitochondrial Biogenesis, Promise, and Limits
Longevity is not just “more years”—it is the energy, clarity, and resilience to use them well. Pyrroloquinoline quinone (PQQ) is a small, redox-active compound...
Prebiotics and Postbiotics for Longevity: Inulin, GOS, and Butyrate
Aging does not occur in isolation—it unfolds alongside changes in the trillions of microbes that inhabit the gut. Diet, medications, stress, and illness can...
Probiotics for Healthy Aging: Strains, Functions, and Evidence
A healthy gut changes how we age. As the years pass, microbial diversity often narrows, low-grade inflammation rises, and the gut barrier can become...
Pterostilbene for Healthy Aging: How It Compares to Resveratrol
Aging changes how our cells handle energy, stress, and inflammation. Many people know resveratrol—the red-grape polyphenol linked to cardiometabolic health. Pterostilbene is its close...
Quercetin for Longevity: Senotherapeutic Mechanisms and Safety
Quercetin is a dietary flavonol found in onions, capers, apples, and tea. It has drawn attention in longevity circles because it intersects two themes...
Resveratrol for Longevity: Mechanisms, Human Evidence, and Safety
Resveratrol has traveled an unusual path—from a grape-skin compound linked to the “French Paradox” to one of the most studied nutraceuticals touching metabolism, vascular...
Rhodiola for Healthy Aging: Stress Resilience and Recovery
Rhodiola rosea has a long history in high-latitude folk medicine, where people used its root to stay sharp during long winters and heavy workloads....
SAMe for Healthy Aging: Mood, Methylation, and Longevity Context
S-adenosylmethionine (SAMe) sits at a useful intersection of mood, mobility, and cellular maintenance. As the body’s universal methyl donor, it supports neurotransmitter synthesis, phospholipid...
Selenium for Longevity: Thyroid, Antioxidant Defense, and Safety
Selenium is a trace mineral with outsized responsibilities. It anchors a family of enzymes—selenoproteins—that manage redox balance, support thyroid hormone metabolism, and help immune...
Spermidine for Longevity: Autophagy and Cognitive Aging Evidence
Spermidine has moved from obscure polyamine to a headline term in healthy aging. It sits at the intersection of cell maintenance, cognition, and cardiometabolic...
Sulforaphane for Longevity: NRF2 Activation and Cellular Defense
Sulforaphane—the isothiocyanate released when we crush or chew certain cruciferous vegetables—turns on the body’s internal defense programs. By activating NRF2, a master switch for...
Taurine and Aging: Potential Benefits, Limits, and Research Gaps
Taurine has moved from a footnote on energy drink labels to a leading candidate in longevity conversations. As a conditionally essential amino acid found...
TUDCA for Healthy Aging: Cellular Stress and Mitochondrial Support
TUDCA (tauroursodeoxycholic acid) is a bile acid derivative with a rare combination: it behaves like a chemical chaperone that dampens endoplasmic reticulum (ER) stress,...
Urolithin A for Healthy Aging: Mitochondrial Health and Muscle Function
Urolithin A has become a leading example of how targeted nutrition can interact with core aging biology. It is a postbiotic—made by your gut...
Vitamin C for Healthy Aging: Collagen Turnover and Antioxidant Support
Vitamin C sits at the intersection of structure and defense. As a required cofactor for enzymes that stabilize collagen, it supports tendons, ligaments, cartilage,...
Vitamin D and K2 for Aging: Bone and Cardiovascular Health
Vitamins D and K2 sit at the center of a simple but powerful idea: move calcium to the right places and keep it out...