Evidence-Based Supplement & Herb Guides

BTK Mutation Test: CLL Drug Resistance Marker and Mutation Meaning

Learn what a BTK mutation test means in CLL, how C481 and other variants cause BTK inhibitor resistance, and how positive or negative results are interpreted.

A BTK mutation test looks for acquired changes in the Bruton tyrosine kinase gene that can help explain resistance to BTK inhibitor treatment in...

CALR Mutation Test: Essential Thrombocythemia, Myelofibrosis, Platelets, and Mutation Meaning

Learn how CALR mutation testing helps diagnose essential thrombocythemia and myelofibrosis, what type 1 and type 2 variants mean, and how results affect risk.

A CALR mutation test looks for acquired mutations in the calreticulin gene that are strongly associated with certain myeloproliferative neoplasms, especially essential thrombocythemia (ET)...

CCND1/IGH Fusion Test: Mantle Cell Lymphoma, Cyclin D1, and FISH Result

Learn how CCND1/IGH FISH detects t(11;14) in mantle cell lymphoma, what positive and negative results mean, and how cyclin D1 and SOX11 support diagnosis.

A CCND1/IGH fusion test looks for the genetic rearrangement created by t(11;14)(q13;q32), the hallmark chromosome abnormality in most mantle cell lymphomas (MCL). The translocation...

CD19 Test: B-Cell Leukemia, Lymphoma, CAR-T Marker, and Positive Staining

Learn what a CD19 test shows in B-cell leukemia and lymphoma, how positive staining is interpreted, and why CD19 matters before and after CAR-T therapy.

A CD19 test checks whether cells express CD19, a surface protein found across most of the B-cell lineage. In hematologic cancer, CD19 is usually...

CD20 Test: B-Cell Lymphoma Marker, B-Cell Lineage, and Positive Staining

Learn what CD20-positive staining means in B-cell lymphoma, how flow cytometry and IHC differ, and why CD20 expression can change after targeted therapy.

A CD20 test checks whether cells express CD20, a surface protein found on most mature B lymphocytes. In lymphoma diagnosis, CD20 is commonly assessed...

CD22 Test: B-Cell Leukemia, Lymphoma Marker, and Positive Staining

Learn what a CD22 test shows in B-cell leukemia and lymphoma, what positive or dim staining means, and how CD22 can affect diagnosis, treatment, and MRD testing.

A CD22 test looks for CD22 protein on or within B cells and is used mainly to help classify B-cell leukemias and lymphomas. CD22...

CD30 Test: Hodgkin Lymphoma, T-Cell Lymphoma, Positive Staining, and Marker Meaning

Understand what a CD30 test means in Hodgkin and T-cell lymphomas, how positive staining is interpreted, and when CD30 expression may affect diagnosis and targeted therapy.

A CD30 test looks for CD30 protein on abnormal lymphoid cells and is especially important in the diagnosis of classic Hodgkin lymphoma and anaplastic...

CD33 Test: AML Marker, Myeloid Blasts, and Positive Staining

Learn what a CD33 test means in AML, how myeloid blast positivity is interpreted, and how CD33 expression can affect leukemia diagnosis, targeted treatment, and MRD follow-up.

A CD33 test checks whether blood or bone marrow cells express CD33, a protein associated mainly with myeloid development. It is commonly included in...

CD34 Test: Leukemia Blast Marker, Stem Cell Marker, and Positive Staining

Understand what a CD34 test means in leukemia and stem cell testing, how positive blast staining is interpreted, and why CD34 alone does not diagnose acute leukemia.

A CD34 test identifies cells that express CD34, a protein found on many early blood-forming stem and progenitor cells and on vascular endothelial cells....

CD38 Test: Myeloma Marker, CLL Marker, and Positive Staining

Learn what a CD38 test means in multiple myeloma and CLL, how positive staining is interpreted, and how anti-CD38 therapy can change flow cytometry and MRD testing.

A CD38 test measures expression of CD38, a surface protein found at very high levels on plasma cells and at variable levels on other...

CD138 Test: Plasma Cell Marker, Myeloma, and Bone Marrow Assessment

Understand what a CD138 test shows in bone marrow, what positive plasma-cell staining means, and how CD138 helps assess multiple myeloma and related disorders.

A CD138 test helps pathologists identify plasma cells in bone marrow or tissue, especially when multiple myeloma or another plasma cell disorder is being...

Chronic Lymphocytic Leukemia (CLL) FISH Panel: del17p, del11q, Trisomy 12, and Prognosis

Understand CLL FISH results for del(17p), del(11q), trisomy 12, and del(13q), including what they mean for TP53 risk, prognosis, repeat testing, and treatment planning.

A CLL FISH panel looks for selected chromosome changes inside chronic lymphocytic leukemia cells. The most familiar targets include deletion 17p, deletion 11q, trisomy...

CLL IGHV Mutation Test: Prognosis, Mutation Status, and Treatment Risk

Understand CLL IGHV mutation testing, the 98% mutated/unmutated cutoff, what IGHV means for prognosis, and how it fits with TP53, FISH, and modern treatment decisions.

The CLL IGHV mutation test measures how much the immunoglobulin heavy-chain variable gene in chronic lymphocytic leukemia cells has changed from its inherited germline...

ClonoSEQ Test: MRD Monitoring in Leukemia, Lymphoma, Myeloma, and Result Meaning

Learn how the ClonoSEQ MRD test tracks residual leukemia, lymphoma, and myeloma, what positive or undetectable results mean, and why sample sensitivity matters.

The ClonoSEQ test is a next-generation sequencing test that can detect and measure very small numbers of blood cancer cells left after treatment, called...

CXCR4 Mutation Test: Waldenstrom Macroglobulinemia, Mutation Status, and Disease Meaning

Understand CXCR4 mutation testing in Waldenstrom macroglobulinemia, including positive and negative results, common variants, prognosis, BTK inhibitor response, and test limits.

A CXCR4 mutation test looks for acquired changes in the CXCR4 gene in Waldenström macroglobulinemia (WM) cells. About 30%–40% of people with WM have...

Cyclin D1 Test for Mantle Cell Lymphoma: Positive Staining and Diagnostic Meaning

Learn what a cyclin D1 test means in mantle cell lymphoma, including positive nuclear staining, CCND1 rearrangements, negative results, SOX11, FISH, and key diagnostic pitfalls.

A cyclin D1 test helps pathologists decide whether an abnormal B-cell population has the molecular pattern expected in mantle cell lymphoma (MCL). The test...

DNMT3A Mutation Test: AML, Clonal Hematopoiesis, Myeloid Neoplasms, and Mutation Meaning

Understand DNMT3A mutation test results in AML and clonal hematopoiesis, including R882 variants, VAF, CHIP and CCUS, prognosis, remission persistence, and follow-up meaning.

A DNMT3A mutation test looks for acquired changes in the DNMT3A gene, an important regulator of DNA methylation and blood-cell development. DNMT3A mutations are...

Double-Hit Lymphoma FISH Panel: MYC, BCL2, BCL6, and Rearrangement Status

Learn how a double-hit lymphoma FISH panel interprets MYC, BCL2, and BCL6 rearrangements, including double-hit, triple-hit, double-expressor, and modern classification meaning.

A double-hit lymphoma FISH panel looks for chromosome rearrangements involving MYC, BCL2, and BCL6 in an aggressive B-cell lymphoma. These rearrangements matter because certain...

FLT3 Mutation Test: AML Risk, Mutation Status, Prognosis, and Result Meaning

Understand FLT3 mutation test results in AML, including ITD vs TKD, ELN 2022 risk, allelic ratio, VAF, targeted therapy, MRD, relapse retesting, and prognosis.

An FLT3 mutation test checks acute myeloid leukemia (AML) cells for activating changes in the FLT3 gene, most commonly an internal tandem duplication (FLT3-ITD)...

Hematologic Cancer Biomarker Panel: Leukemia, Lymphoma, Myeloma Markers, and Diagnosis

Learn how hematologic cancer biomarker panels use flow cytometry, IHC, FISH, PCR, NGS, and protein studies to diagnose and classify leukemia, lymphoma, and myeloma.

A hematologic cancer biomarker panel is not one universal blood test. It is a coordinated set of laboratory methods used to identify, classify, risk-stratify,...