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Guardant360 Test: Liquid Biopsy, Cancer Mutations, ctDNA, and Genomic Profiling

Learn how Guardant360 Liquid CDx analyzes ctDNA for cancer mutations, what the current FDA-approved panel reports, how companion-diagnostic findings guide therapy, and why negative plasma results may need tissue confirmation.

Guardant360 is a family of blood-based genomic profiling tests used mainly for people with advanced solid cancers. The current U.S. FDA-approved platform, Guardant360 Liquid...

KRAS Liquid Biopsy Test: Colon, Lung, Pancreatic Cancer, Mutation Status, and ctDNA Meaning

Understand what a KRAS liquid biopsy measures, how ctDNA results are interpreted, and what KRAS mutations can mean in colorectal, lung, and pancreatic cancer.

A KRAS liquid biopsy is a blood test that looks for tumor-derived KRAS mutations in circulating tumor DNA (ctDNA). It can help characterize some...

Liquid Biopsy Resistance Mutation Test: Cancer Drug Resistance Markers and Mutation Detection

Learn how liquid biopsy resistance mutation tests detect ctDNA markers of cancer drug resistance, when testing is useful, how results are read, and why negative results may need tissue confirmation.

A liquid biopsy resistance mutation test looks for genetic changes in circulating tumor DNA (ctDNA) that can explain why a cancer has stopped responding—or...

Liquid Biopsy Test: Circulating Tumor DNA, Blood-Based Tumor Testing, and Mutation Detection

Learn how liquid biopsy tests use circulating tumor DNA for blood-based cancer profiling, mutation detection, treatment selection, resistance testing, MRD monitoring, and result interpretation.

A liquid biopsy is a laboratory test that looks for cancer-related material in blood or another body fluid instead of removing a piece of...

OncoBEAM Test: ctDNA Mutation Testing, Digital PCR, and Blood-Based Monitoring

Learn how the OncoBEAM ctDNA test uses BEAMing digital PCR for sensitive mutation detection, RAS testing in metastatic colorectal cancer, resistance monitoring, and blood-based result interpretation.

OncoBEAM is a highly sensitive liquid-biopsy approach that uses BEAMing digital PCR to detect selected tumor mutations in circulating tumor DNA (ctDNA) from plasma....

RaDaR Test: ctDNA MRD, Cancer Monitoring, and Recurrence Detection

Learn how the RaDaR ctDNA test uses personalized tumor mutations to detect MRD, monitor recurrence risk, and interpret positive or negative results.

RaDaR is a personalized blood test that looks for tiny amounts of circulating tumor DNA (ctDNA) after a cancer has been treated or while...

Signatera Test: ctDNA MRD, Cancer Recurrence, and Personalized Monitoring

Understand how the Signatera ctDNA test detects personalized MRD, what positive and negative results mean, and how serial testing may signal cancer recurrence.

Signatera is a personalized circulating tumor DNA (ctDNA) blood test used to look for molecular residual disease (MRD) and to monitor cancer over time....

Tempus xF Test: Liquid Biopsy, Cancer Genomics, ctDNA, and Mutation Results

Learn what the Tempus xF liquid biopsy tests, how xF differs from xF+, and how to interpret ctDNA mutations, negative results, MSI-H, and bTMB.

Tempus xF is a blood-based next-generation sequencing test that analyzes circulating tumor DNA (ctDNA) to look for genomic changes in solid cancers. Its main...

Tumor-Informed ctDNA Test: Personalized MRD Monitoring, Recurrence Detection, and Result Meaning

Learn how tumor-informed ctDNA tests personalize MRD monitoring, what positive and negative results mean, and how they compare with tumor-naive blood testing.

A tumor-informed ctDNA test is a personalized blood test built from genetic changes found in a patient’s own cancer. It is most often used...

Tumor-Naive ctDNA Test: Blood-Based Cancer Monitoring Without Tumor Tissue

A tumor-naive ctDNA test looks for cancer-related DNA signals in blood without first sequencing that patient’s tumor to build a custom assay. Also called...

ALK Test for Anaplastic Large Cell Lymphoma: Fusion Marker, Positive Result, and Tumor Classification

Learn how ALK testing helps classify anaplastic large cell lymphoma, what positive IHC or ALK rearrangement results mean, and when FISH or molecular confirmation is used.

An ALK test helps determine whether an anaplastic large cell lymphoma (ALCL) belongs to the ALK-positive subtype, a biologically distinct form of systemic T-cell...

BCL2 Rearrangement Test: Follicular Lymphoma, Rearrangement Status, and FISH Result

Understand BCL2 rearrangement testing in follicular lymphoma, including IGH::BCL2, t(14;18), FISH results, negative tests, and how findings affect tumor classification.

A BCL2 rearrangement test looks for a structural change involving the BCL2 gene, most often the classic IGH::BCL2 fusion created by t(14;18)(q32;q21). This abnormality...

BCR-ABL1 Quantitative PCR Test: CML Monitoring, Molecular Response, and Transcript Level

Learn how BCR-ABL1 quantitative PCR monitors CML, including International Scale percentages, MMR, MR4/MR4.5, milestone timing, rising results, and undetectable transcripts.

The BCR-ABL1 quantitative PCR test is the main blood test used to monitor molecular response in chronic myeloid leukemia (CML). It measures the amount...

BCR-ABL1 Test: Chronic Myeloid Leukemia, Philadelphia Chromosome, and Molecular Diagnosis

Learn how BCR-ABL1 testing detects the Philadelphia chromosome in CML, how PCR, FISH, and karyotyping differ, and what positive or negative results mean.

A BCR-ABL1 test looks for the abnormal BCR::ABL1 fusion gene that defines chronic myeloid leukemia (CML) and can also occur in some acute leukemias....

Beta-2 Microglobulin Test for Myeloma: Staging, Prognosis, Tumor Burden, and Kidney Function

Learn how beta-2 microglobulin is used in multiple myeloma staging and prognosis, why kidney function changes the result, and how to interpret high levels.

A beta-2 microglobulin test measures a small protein in blood that is used as part of staging and prognosis in multiple myeloma. In myeloma,...

BTK Mutation Test: CLL Drug Resistance Marker and Mutation Meaning

Learn what a BTK mutation test means in CLL, how C481 and other variants cause BTK inhibitor resistance, and how positive or negative results are interpreted.

A BTK mutation test looks for acquired changes in the Bruton tyrosine kinase gene that can help explain resistance to BTK inhibitor treatment in...

CALR Mutation Test: Essential Thrombocythemia, Myelofibrosis, Platelets, and Mutation Meaning

Learn how CALR mutation testing helps diagnose essential thrombocythemia and myelofibrosis, what type 1 and type 2 variants mean, and how results affect risk.

A CALR mutation test looks for acquired mutations in the calreticulin gene that are strongly associated with certain myeloproliferative neoplasms, especially essential thrombocythemia (ET)...

CCND1/IGH Fusion Test: Mantle Cell Lymphoma, Cyclin D1, and FISH Result

Learn how CCND1/IGH FISH detects t(11;14) in mantle cell lymphoma, what positive and negative results mean, and how cyclin D1 and SOX11 support diagnosis.

A CCND1/IGH fusion test looks for the genetic rearrangement created by t(11;14)(q13;q32), the hallmark chromosome abnormality in most mantle cell lymphomas (MCL). The translocation...

CD19 Test: B-Cell Leukemia, Lymphoma, CAR-T Marker, and Positive Staining

Learn what a CD19 test shows in B-cell leukemia and lymphoma, how positive staining is interpreted, and why CD19 matters before and after CAR-T therapy.

A CD19 test checks whether cells express CD19, a surface protein found across most of the B-cell lineage. In hematologic cancer, CD19 is usually...

CD20 Test: B-Cell Lymphoma Marker, B-Cell Lineage, and Positive Staining

Learn what CD20-positive staining means in B-cell lymphoma, how flow cytometry and IHC differ, and why CD20 expression can change after targeted therapy.

A CD20 test checks whether cells express CD20, a surface protein found on most mature B lymphocytes. In lymphoma diagnosis, CD20 is commonly assessed...