DPYD Genetic Test: Fluoropyrimidine Toxicity, 5-FU, Capecitabine, and Results
A DPYD genetic test identifies inherited variants that can reduce dihydropyrimidine dehydrogenase, or DPD, the main enzyme that breaks down fluorouracil. Reduced DPD activity...
Fluoropyrimidine Pharmacogenetic Test: DPYD, 5-FU, Capecitabine Toxicity, and Results
A fluoropyrimidine pharmacogenetic test is a pre-treatment safety assessment for people who may receive intravenous 5-fluorouracil or oral capecitabine. It usually examines DPYD, the...
G6PD Genetic Test: Medication Hemolysis Risk, Deficiency, and Results
A G6PD genetic test looks for inherited changes in the glucose-6-phosphate dehydrogenase gene that can make red blood cells unusually vulnerable to oxidative stress....
HLA-A*31:01 Genetic Test: Carbamazepine Hypersensitivity Risk and Results
An HLA-A31:01 genetic test estimates whether a person has a higher-than-average risk of immune-mediated hypersensitivity from carbamazepine. The allele is associated with several reaction...
HLA-B*15:02 Genetic Test: Carbamazepine Skin Reaction Risk and Results
The HLA-B15:02 genetic test is used to reduce the risk of Stevens–Johnson syndrome and toxic epidermal necrolysis before carbamazepine or certain related antiseizure medicines...
HLA-B*57:01 Genetic Test: Abacavir Hypersensitivity Risk and Results
The HLA-B57:01 genetic test is a standard safety check before abacavir is used to treat HIV. Abacavir can cause a serious, sometimes fatal, multisystem...
HTR2A Genetic Test: Antidepressant Response, Side Effects, and Results
An HTR2A genetic test examines variants in the gene for the serotonin 2A receptor, a brain signaling protein involved in mood, cognition, sleep, and...
IFNL3 Genetic Test: Hepatitis C Treatment Response and Results
An IFNL3 genetic test looks for inherited variants that once helped predict how likely a person with hepatitis C was to respond to interferon-based...
NAT2 Genetic Test: Isoniazid Metabolism, Slow Acetylator Status, and Results
A NAT2 genetic test estimates how quickly a person is likely to acetylate isoniazid, an important medicine used in treatment regimens for tuberculosis disease...
NUDT15 Genetic Test: Thiopurine Toxicity, Leukopenia Risk, and Results
A NUDT15 genetic test helps estimate whether standard doses of thiopurine medicines could cause excessive bone marrow suppression. Thiopurines—including mercaptopurine, azathioprine, and thioguanine—are used...
OPRM1 Genetic Test: Opioid Response, Pain Treatment, and Results
An OPRM1 genetic test looks for inherited variation in the gene that makes the mu-opioid receptor, a major target of medicines such as morphine,...
Pain Medication Pharmacogenetic Test: Opioids, CYP2D6, OPRM1, and Results
A pain medication pharmacogenetic test looks for inherited gene variants that may change how a person processes or responds to certain analgesics. The clearest...
Pharmacogenetic Panel Test: Medication Response, Gene Variants, and Results
A pharmacogenetic panel test examines several inherited genes at once to identify medication responses that may differ from the average. It can reveal slower...
Psychiatric Pharmacogenetic Test: Antidepressants, Antipsychotics, Genes, and Results
A psychiatric pharmacogenetic test analyzes inherited gene variants that may affect the metabolism, exposure, or tolerability of selected antidepressants and antipsychotics. The strongest prescribing...
RYR1 Genetic Test: Malignant Hyperthermia Risk and Anesthesia Results
An RYR1 genetic test looks for inherited variants associated with malignant hyperthermia susceptibility, a potentially fatal reaction to certain general anesthetics and the muscle...
SLC6A4 Genetic Test: Antidepressant Response, Serotonin Transporter, and Results
An SLC6A4 genetic test examines variants in the gene that encodes the serotonin transporter, the protein blocked by selective serotonin reuptake inhibitor antidepressants. The...
SLCO1B1 Genetic Test: Statin Muscle Risk, Simvastatin, and Results
An SLCO1B1 genetic test looks for inherited variants that can reduce the liver’s uptake of certain statins, especially simvastatin. When that transport is reduced,...
Statin Pharmacogenetic Test: SLCO1B1, Muscle Pain Risk, and Results
A statin pharmacogenetic test examines inherited variants that can change how the body transports or metabolizes cholesterol-lowering medicines. The most clinically established finding is...
Tacrolimus Pharmacogenetic Test: CYP3A5, Dose, Transplant, and Results
A tacrolimus pharmacogenetic test examines CYP3A5, a gene that strongly influences how quickly many transplant recipients clear tacrolimus. People who make functional CYP3A5 enzyme—called...
Thiopurine Pharmacogenetic Test: TPMT, NUDT15, Toxicity Risk, and Results
A thiopurine pharmacogenetic test examines TPMT and NUDT15, two genes that strongly influence tolerance to azathioprine, mercaptopurine, and thioguanine. Reduced function in either pathway...