OPRM1 Genetic Test: Opioid Response, Pain Treatment, and Results
An OPRM1 genetic test looks for inherited variation in the gene that makes the mu-opioid receptor, a major target of medicines such as morphine,...
Pain Medication Pharmacogenetic Test: Opioids, CYP2D6, OPRM1, and Results
A pain medication pharmacogenetic test looks for inherited gene variants that may change how a person processes or responds to certain analgesics. The clearest...
Pharmacogenetic Panel Test: Medication Response, Gene Variants, and Results
A pharmacogenetic panel test examines several inherited genes at once to identify medication responses that may differ from the average. It can reveal slower...
Psychiatric Pharmacogenetic Test: Antidepressants, Antipsychotics, Genes, and Results
A psychiatric pharmacogenetic test analyzes inherited gene variants that may affect the metabolism, exposure, or tolerability of selected antidepressants and antipsychotics. The strongest prescribing...
RYR1 Genetic Test: Malignant Hyperthermia Risk and Anesthesia Results
An RYR1 genetic test looks for inherited variants associated with malignant hyperthermia susceptibility, a potentially fatal reaction to certain general anesthetics and the muscle...
SLC6A4 Genetic Test: Antidepressant Response, Serotonin Transporter, and Results
An SLC6A4 genetic test examines variants in the gene that encodes the serotonin transporter, the protein blocked by selective serotonin reuptake inhibitor antidepressants. The...
SLCO1B1 Genetic Test: Statin Muscle Risk, Simvastatin, and Results
An SLCO1B1 genetic test looks for inherited variants that can reduce the liver’s uptake of certain statins, especially simvastatin. When that transport is reduced,...
Statin Pharmacogenetic Test: SLCO1B1, Muscle Pain Risk, and Results
A statin pharmacogenetic test examines inherited variants that can change how the body transports or metabolizes cholesterol-lowering medicines. The most clinically established finding is...
Tacrolimus Pharmacogenetic Test: CYP3A5, Dose, Transplant, and Results
A tacrolimus pharmacogenetic test examines CYP3A5, a gene that strongly influences how quickly many transplant recipients clear tacrolimus. People who make functional CYP3A5 enzyme—called...
Thiopurine Pharmacogenetic Test: TPMT, NUDT15, Toxicity Risk, and Results
A thiopurine pharmacogenetic test examines TPMT and NUDT15, two genes that strongly influence tolerance to azathioprine, mercaptopurine, and thioguanine. Reduced function in either pathway...
TPMT Genetic Test: Thiopurine Toxicity, Azathioprine, Mercaptopurine, and Results
A TPMT genetic test identifies inherited variants that reduce thiopurine S-methyltransferase activity and increase sensitivity to azathioprine, mercaptopurine, and thioguanine. TPMT normally helps divert...
UGT1A1 Genetic Test: Irinotecan Toxicity, Gilbert Syndrome, and Results
A UGT1A1 genetic test has two main clinical uses. In oncology, it can identify patients who clear the active irinotecan metabolite SN-38 more slowly...
VKORC1 Genetic Test: Warfarin Sensitivity, Dose, and Results
A VKORC1 genetic test examines inherited variation in the gene that makes warfarin’s molecular target. The result most often reported, VKORC1 c.-1639G>A (rs9923231), helps...
Warfarin Pharmacogenetic Test: CYP2C9, VKORC1, CYP4F2, Dose, and Results
A warfarin pharmacogenetic test analyzes inherited variants that help explain why one person may need 1 mg of warfarin a day while another needs...
Alzheimer Disease Genetic Test: APOE, APP, PSEN1, PSEN2, and Results
Alzheimer disease genetic testing can answer very different questions depending on which genes are examined. Rare pathogenic variants in APP, PSEN1, or PSEN2 can...
Amyotrophic Lateral Sclerosis (ALS) Genetic Test: C9orf72, SOD1, TARDBP, and Results
ALS genetic testing looks for inherited or disease-associated changes that may explain why motor neurons are degenerating. The most important first-line targets include the...
Angelman Syndrome Genetic Test: UBE3A, Methylation, Deletion, and Results
Angelman syndrome testing does more than look for a change in the UBE3A gene. The condition results from loss of the active maternal UBE3A...
APOE Genotype Test: Alzheimer Disease Risk, Cholesterol, and Results
An APOE genotype test identifies which common APOE alleles—ε2, ε3, or ε4—you inherited from each biological parent. The result can inform several separate clinical...
Autism Genetic Testing: Chromosomal Microarray, Exome Sequencing, and Results
Genetic testing does not diagnose autism; autism is diagnosed from development, communication, behavior, and clinical observation. Genetic testing looks for an underlying chromosome or...
Becker Muscular Dystrophy Genetic Test: DMD Gene, Muscle Weakness, and Results
Becker muscular dystrophy testing looks for a pathogenic change in the DMD gene, which provides instructions for making dystrophin. Becker muscular dystrophy usually occurs...