Stretching for Longevity: Dynamic, Static, and PNF
Flexibility that you can actually use is a quiet superpower for healthy aging. It helps joints move through full ranges without pain, improves gait...
Technique Fundamentals for Longevity Lifts: Squat, Hinge, Push, Pull
Good technique is not about chasing perfect form; it is about choosing positions that your body can repeat safely as loads rise and decades...
Travel Workouts for Healthy Aging: Hotel Room and Park Circuits
Travel can energize the mind yet disrupt routines that keep you strong, mobile, and steady. The goal of this guide is simple: give you...
VO₂max for Longevity: Interval Playbook
VO₂max reflects how much oxygen your body can deliver and use during hard work. As you age, protecting this capacity pays off in everyday...
Warm-Ups for Longevity Training: Joint Prep and Activation
A smart warm-up does more than “get loose.” It prepares joints, wakes up stabilizers, and sets your nervous system for the session ahead. For...
Zone 2 Training for Healthy Aging: How Much and How to Do It
Zone 2 is steady, sustainable aerobic work that keeps you breathing a little harder while still able to speak in complete sentences. It builds...
Acarbose and Longevity: Lessons from Animal Data and Human Signals
Acarbose is an oral diabetes medicine with a simple idea behind it: slow the digestion of complex carbohydrates so post-meal blood sugar rises less....
Autophagy-Targeted Drugs for Longevity: mTORC1-Selective and ULK1 Pathways
Autophagy—the cell’s self-recycling program—declines with age. When this cleanup falters, damaged proteins and organelles accumulate, stress signaling rises, and tissues lose resilience. Drug developers...
Combination Longevity Trials: Stacking Mechanisms and Smarter Study Design
Designing trials that test more than one aging intervention at a time is no longer a fringe idea. Biology of aging is multifactorial; metabolism,...
Crosslink Breakers for Vascular Aging: What Comes After Alagebrium
The stiffening of large arteries is one of aging’s most measurable signatures. As collagen and elastin accumulate non-enzymatic crosslinks, vessels lose their snap-back and...
Epigenetic Rejuvenation Compounds: Small-Molecule Reprogrammers
Aging reshapes gene expression long before disease appears. Chromatin loosens in the wrong places, tightens in others, and methyl marks drift in patterns that...
Exosomes and Extracellular Vesicles in Aging: Promise and Pitfalls
Exosomes and other extracellular vesicles (EVs) are tiny, membrane-bound packages that cells send and receive. They carry proteins, lipids, and genetic messages that can...
GLP-1s and Longevity: Weight, Cardiometabolic Risk, and Open Questions
Glucagon-like peptide-1 receptor agonists (GLP-1s) have moved from diabetes drugs to a broader platform that reshapes appetite, weight, and cardiometabolic risk. Their appeal for...
Hormone-Based Rejuvenation: Klotho, FGF21, and GDF11 Candidates
Aging biology is increasingly defined by circulating signals that coordinate stress responses, nutrient handling, and tissue repair. Three hormones—Klotho, FGF21, and GDF11—sit near the...
Metformin for Healthy Aging: What the Trials Show and Do Not
Metformin has earned unusual attention for a decades-old, inexpensive drug. Beyond glucose control, it appears to influence pathways tied to aging: cellular energy sensing,...
Microbiome Therapeutics for Healthy Aging: Consortia, FMT, and Postbiotics
The human microbiome shifts with age in ways that touch metabolism, immunity, and brain function. Some changes are adaptive; others drive inflammation, insulin resistance,...