Beetroot and Nitrate Supplements for Longevity: Vascular Function and Exercise Capacity
Blood vessels age with us. As nitric oxide signaling wanes, arteries stiffen, endothelial responses dull, and blood pressure trends upward. Dietary nitrates—found in beetroot and leafy greens—offer a practical way to bolster nitric oxide through an alternate route that does not rely on stressed endothelial enzymes alone. In older adults, this can translate into smoother vascular control, modest blood...
Berberine for Healthy Aging: Glucose, Lipids, and AMPK
As we age, metabolism gets noisier: insulin signaling drifts, lipids creep up, and low-grade inflammation blunts cellular responses. Berberine—a plant alkaloid from Coptis, barberry, and related botanicals—has re-emerged as a practical tool for metabolic tune-ups. It acts on several levers at once: AMP-activated protein kinase (AMPK), gut microbiota, bile acid signaling, and LDL receptor expression. The result, in trials,...
Beta Alanine and Carnosine for Healthy Aging: Performance and Fatigue
Aging changes how muscles feel and perform. Short bursts that once felt easy—climbing stairs, carrying groceries, rising from the floor—start to sting with “burn” sooner, and recovery takes longer. Two related tools, beta alanine and carnosine, target this sensation where it starts: in the muscle cell’s handling of acid during hard work. Beta alanine raises intramuscular carnosine, a naturally...
Betaine TMG for Longevity: Methylation and Homocysteine
As we age, small biochemical drifts can compound into larger health problems. One of the best-studied signals is homocysteine, a sulfur-containing amino acid tied to methylation, vascular aging, and metabolic stress. Betaine—also called trimethylglycine (TMG)—is a simple nutrient that donates methyl groups to recycle homocysteine back to methionine. That single transfer supports healthy methylation reactions across the body, from...
Boswellia for Healthy Aging: Joint Comfort Without Reliance on NSAIDs
Modern healthy aging often means preserving the freedom to walk, climb, and stay active without leaning hard on nonsteroidal anti-inflammatory drugs (NSAIDs). Boswellia (Boswellia serrata) has emerged as a promising option for joint comfort and mobility, particularly for knees and hands. Its resin—long used in traditional medicine—contains boswellic acids that influence inflammatory signaling in a way that differs from...
Carnitine for Healthy Aging: L Carnitine Tartrate vs Acetyl L Carnitine
A well-planned carnitine strategy can support energy, recovery, and cognitive clarity as we age. Yet “carnitine” is not one thing. L-carnitine tartrate (LCT) and acetyl-L-carnitine (ALCAR) behave differently in the body and serve different goals. LCT primarily replenishes the systemic carnitine pool that ferries fatty acids into mitochondria for energy, with practical benefits for exercise recovery and work capacity....
Choline and Citicoline for Cognitive Longevity: What to Know
Cognitive longevity is not just about preserving memory—it is about sustaining clear attention, flexible thinking, and day-to-day independence. Choline sits at the center of that effort. It supports acetylcholine synthesis for attention and memory, builds brain cell membranes, and donates methyl groups for healthy homocysteine metabolism. Citicoline (CDP-choline) adds another layer: it is a choline donor paired with cytidine...
Citrus Bergamot for Longevity: Lipids and Cardiometabolic Aging
Bergamot (Citrus bergamia) is a small citrus fruit from Calabria whose peel and juice are unusually rich in flavonoids and related polyphenols. In aging adults, these compounds matter because they influence lipid handling, vascular inflammation, and hepatic fat—three levers that shape long-term cardiometabolic risk. People usually meet bergamot in perfumes or Earl Grey tea, yet standardized oral extracts are...
Collagen Peptides for Aging: Skin Elasticity and Joint Support
Collagen sits at the center of healthy connective tissue. With age, its production slows while enzymes break down existing fibers, leading to drier skin, fine lines, and stiffer joints. Collagen peptides—small chains produced by hydrolyzing larger collagen proteins—aim to counter that decline by supplying characteristic amino acids such as glycine, proline, and hydroxyproline and by signaling cells to rebuild...
CoQ10 for Longevity: Ubiquinol and Ubiquinone and Cellular Energy
Aging changes how our cells make and use energy. Mitochondria—the tiny power plants inside cells—must keep electrons moving cleanly along the respiratory chain. Coenzyme Q10 (CoQ10) sits at the center of that process, shuttling electrons, buffering oxidative stress, and helping tissues with high energy demands, like the heart and skeletal muscle. Circulating CoQ10 levels tend to fall with age...
Creatine for Healthy Aging: Muscle, Brain, and Safety
Aging reshapes how we produce and use energy. That shift shows up in everyday life: climbing stairs, remembering names, recovering after a walk or workout. Creatine sits at the center of cellular energy transfer, buffering ATP where and when tissues need it most—especially in fast-twitch muscle fibers and energetically demanding brain regions. Thoughtful supplementation can narrow age-related gaps in...
Curcumin for Healthy Aging: Inflammation and Bioavailability
Curcumin—the principal polyphenol in turmeric—sits at the intersection of diet, inflammation, and longevity science. It targets immune pathways involved in “inflammaging,” the low-grade, chronic inflammation that rises with age and contributes to joint degeneration, metabolic drift, and cognitive decline. Yet curcumin’s promise is tempered by poor oral absorption and rapid metabolism, which is why delivery form matters as much...
DHEA Supplementation in Aging: Endocrine Context, Benefits, and Cautions
Dehydroepiandrosterone (DHEA) sits upstream of testosterone and estrogens and declines steadily from early adulthood. That quiet drop can intersect with age-related changes in strength, mood, libido, and body composition. Yet DHEA is not a simple “hormone booster.” It behaves as a precursor that tissues convert locally, and outcomes vary by sex, age, dose, and health status. This guide explains...
EGCG for Healthy Aging: Green Tea Extract and Cardiometabolic Health
Epigallocatechin gallate (EGCG) is the best-studied catechin in green tea. It sits at the crossroads of metabolism, vascular biology, and cellular defense. Observational and clinical data point to modest improvements in weight control, lipid balance, and endothelial function when EGCG is used thoughtfully. At the same time, dose and formulation matter: supplements can deliver high catechin loads quickly, which...
Fisetin for Healthy Aging: A Practical Guide to Senolytic Use
Fisetin is a plant-derived flavonol that drew attention when researchers observed it could help clear damaged “senescent” cells in animal models. Senescent cells stop dividing yet persist; they release inflammatory signals that can drive tissue wear, metabolic drift, and frailty with age. The promise of fisetin—and senolytics more broadly—is to reduce that burden in short, intermittent pulses rather than...
Ginseng for Healthy Aging: Energy, Immunity, and Evidence
Aging well is not just about adding years—it is about preserving energy, attention, and resilience. Among botanical options, ginseng has a long record in traditional medicine and a growing modern evidence base. Research explores how ginseng’s ginsenosides influence stress responses, inflammation, and cellular energy systems, with outcomes measured in fatigue, cognition, immune function, and quality of life. Yet results...
