Evidence-Based Supplement & Herb Guides

B Vitamins for Aging: B12, Folate, and B6 for Homocysteine

Learn how vitamin B12, folate, and B6 affect homocysteine in aging, when to test, which supplement forms and doses make sense, and how to avoid safety mistakes.

Homocysteine is a normal amino acid byproduct, but it becomes more useful as a health clue when it stays elevated. Vitamin B12, folate, and...

Beetroot and Nitrate Supplements for Longevity: Vascular Function and Exercise Capacity

Beetroot and nitrate supplements may support vascular function, blood pressure, and exercise capacity through nitric oxide. Learn dosing, timing, benefits, and safety.

Beetroot and nitrate supplements support healthy aging mainly by increasing nitric oxide, a short-lived signaling molecule that helps blood vessels relax, improves blood flow,...

Berberine for Healthy Aging: Glucose, Lipids, and AMPK

Berberine may support healthy aging by improving glucose, insulin resistance, lipids, and AMPK signaling. Learn who benefits, how to dose it, and when to avoid it.

Berberine is a plant-derived compound with the strongest supplement evidence in cardiometabolic health: blood glucose, insulin resistance, triglycerides, LDL cholesterol, and fatty liver markers....

Beta Alanine and Carnosine for Healthy Aging: Performance and Fatigue

Beta alanine raises muscle carnosine and may help healthy adults reduce high-intensity muscle fatigue, improve interval tolerance, and support training quality with safe dosing.

Beta alanine is best known as a sports supplement, but its most interesting use in healthy aging is more specific: it helps muscle cells...

Betaine TMG for Longevity: Methylation and Homocysteine

Betaine TMG supports homocysteine metabolism through methylation, but it is not a proven longevity pill. Learn who may benefit, what dose to consider, and which labs to monitor.

Betaine, also called trimethylglycine or TMG, sits at the crossroads of nutrition, methylation, liver metabolism, and homocysteine control. It is not a proven longevity...

Boswellia for Healthy Aging: Joint Comfort Without Reliance on NSAIDs

Boswellia may support knee osteoarthritis comfort and mobility while reducing reliance on frequent NSAID use. Learn evidence, dosing, safety, and how to choose a quality supplement.

Boswellia is best understood as a joint-comfort supplement, not a painkiller replacement. Extracts from the resin of Boswellia serrata, also called Indian frankincense, contain...

Carnitine for Healthy Aging: L Carnitine Tartrate vs Acetyl L Carnitine

Compare L-carnitine tartrate and acetyl-L-carnitine for healthy aging, including muscle recovery, cognition, dosing ranges, safety, and TMAO concerns.

Carnitine helps move long-chain fatty acids into mitochondria, where cells turn them into usable energy. That role makes it attractive for healthy aging, especially...

Choline and Citicoline for Cognitive Longevity: What to Know

Choline supports brain membranes, acetylcholine, and methylation, while citicoline offers a targeted but still unproven option for memory support. Learn food sources, dosing, evidence, and safety.

Choline is an essential nutrient your brain uses to build cell membranes, make acetylcholine, and support methylation, a process tied to homocysteine balance. Citicoline...

Citrus Bergamot for Longevity: Lipids and Cardiometabolic Aging

Citrus bergamot may support healthier LDL cholesterol, triglycerides, and cardiometabolic aging when used with lab tracking, quality products, and risk-based care.

Citrus bergamot is best understood as a lipid-support supplement with a cardiometabolic angle, not as a general “anti-aging” shortcut. The extract comes from Citrus...

Collagen Peptides for Aging: Skin Elasticity and Joint Support

Learn how collagen peptides support aging skin and joints, including realistic benefits, dosing ranges, timing, safety, product quality, and how to track results.

Collagen peptides are small protein fragments made from collagen, the main structural protein in skin, cartilage, tendons, ligaments, and bone. As adults age, collagen...

CoQ10 for Longevity: Ubiquinol and Ubiquinone and Cellular Energy

CoQ10 supports mitochondrial energy and antioxidant function, but it is not proven to extend lifespan. Learn how ubiquinol and ubiquinone compare, who may benefit, how to dose CoQ10, and when safety concerns matter.

Coenzyme Q10, usually shortened to CoQ10, sits at the center of cellular energy production. Your body makes it, your mitochondria use it, and every...

Creatine for Healthy Aging: Muscle, Brain, and Safety

Creatine for healthy aging supports strength, muscle function, and possibly brain energy; learn dosing, safety, kidney lab considerations, and who benefits most.

Creatine is one of the few supplements with a strong reason to belong in a healthy aging discussion. It supports fast energy recycling in...

Curcumin for Healthy Aging: Inflammation and Bioavailability

Curcumin may support healthy aging by modulating inflammation, but bioavailability, dose, product quality, and safety risks determine whether it makes sense.

Curcumin is the bright yellow polyphenol in turmeric that draws attention because it touches two aging-related themes: chronic low-grade inflammation and oxidative stress. In...

DHEA Supplementation in Aging: Endocrine Context, Benefits, and Cautions

DHEA supplementation in aging may raise DHEA-S, testosterone, and estradiol, but anti-aging benefits remain uncertain. Learn the evidence, dosing, testing, side effects, and safety cautions.

DHEA is a hormone precursor made mostly by the adrenal glands. It rises in childhood, peaks in early adulthood, and falls steadily with age....

EGCG for Healthy Aging: Green Tea Extract and Cardiometabolic Health

EGCG from green tea extract may modestly support lipids, glucose, blood pressure, and body composition, but dose and liver safety matter. Learn how to use it wisely.

EGCG is the best-known catechin in green tea and one reason green tea extract appears in many healthy aging supplements. It sits in an...

Fisetin for Healthy Aging: A Practical Guide to Senolytic Use

Fisetin is a promising but investigational senolytic supplement for healthy aging. Learn how it may work, what human evidence shows, dosing models, safety concerns, and how to monitor results.

Fisetin is a plant flavonol found in small amounts in strawberries, apples, persimmons, onions, and cucumbers. Interest in fisetin has grown because lab and...

Ginseng for Healthy Aging: Energy, Immunity, and Evidence

Ginseng may support healthy aging through modest effects on fatigue, immunity, and metabolic signals. Learn the evidence, dosing ranges, safety issues, and who should avoid it.

Ginseng has a long reputation as a tonic for energy, stress resilience, and immune defense, but its real value for healthy aging is more...

Glucosamine and Longevity: What Observational Studies Suggest

Glucosamine has been linked with lower mortality and age-related disease risk in observational studies. Learn what the evidence suggests, where it falls short, and how to use it safely.

Glucosamine is best known as a joint supplement, but several large population studies have linked regular use with lower rates of death and some...

Glycine for Longevity: Sleep, Collagen, and Metabolic Aging

Learn how glycine supports sleep quality, collagen structure, glutathione production, and metabolic aging, with practical dosing, food sources, safety cautions, and tracking tips.

Glycine is a small amino acid with a surprisingly large role in healthy aging. The body uses it to build collagen, make glutathione, support...

GlyNAC for Aging: What Human Studies Suggest for Glutathione and Mitochondria

GlyNAC for aging may support glutathione and mitochondrial function, but human evidence is still early. Learn what studies show, who might benefit, dosing cautions, safety issues, and how to track results.

GlyNAC is a supplement pairing glycine with N-acetylcysteine, two building blocks the body uses to make glutathione. Interest in GlyNAC grew because several human...