Mitochondrial Therapies for Longevity: Elamipretide and mtDNA Editing
Mitochondria do more than make ATP. They organize cellular signaling, shape redox tone, and decide whether cells adapt or fail under stress. When their...
Neuroprotective Emerging Therapies: From Senolytics to ISR Modulators
Age-related brain change is not one process but many. Glial cells shift toward pro-inflammatory states, protein quality control weakens, and the integrated stress response...
Partial Cellular Reprogramming for Longevity: OSK and Safety Considerations
Partial cellular reprogramming—brief, carefully dosed expression of Yamanaka factors—has moved from an intriguing lab trick to a serious candidate for restoring tissue function with...
Plasma-Based Therapies: Therapeutic Exchange and Young Factors
Modern interest in plasma-based interventions sits at the crossroads of aging biology, transfusion medicine, and neurology. Two concepts dominate the conversation. The first is...
Rapamycin and Rapalogs for Longevity: Evidence, Dosing Models, and Risks
Rapamycin and its derivatives (“rapalogs”) sit at a rare intersection: they are established immunosuppressants in transplantation and oncology, yet they also modulate core pathways...
Senescence-Targeted Immunotherapy: Vaccines and CAR-T Approaches
Cellular senescence was once viewed as a biological dead end—a protective stopgap for damaged cells. We now recognize that senescent cells linger, accumulate with...
Senolytics for Healthy Aging: Dasatinib plus Quercetin and Next-Gen Agents
Senescent cells are damaged cells that stop dividing yet refuse to die. They accumulate with age and stress, secrete inflammatory factors, and distort tissue...
Senomorphic Strategies: Taming the SASP without Killing Cells
Modern longevity research increasingly distinguishes between two ways of dealing with damaged, old cells. Senolytics aim to remove them. Senomorphics try something different: they...
Telomerase Gene Therapy for Healthy Aging: Where the Science Stands
Modern aging research is circling a hard question: can restoring telomere maintenance improve tissue function without inviting cancer? Telomerase gene therapy aims to do...
Thymus Regeneration and Immune Rejuvenation: TRIIM and Beyond
The thymus shapes our T-cell repertoire, the adaptive guard that recognizes new pathogens and tumor antigens. Yet this organ involutes early in adulthood: functional...
Autophagy Made Simple for Healthy Aging
Autophagy is your cells’ housekeeper and recycler. It breaks down worn-out parts, clears faulty proteins, and frees up materials to build new, better components....
Build Your Hormesis Plan for Longevity: Simple, Safe, Repeatable
Well-designed hormesis turns small, brief stress into lasting resilience. The key is dose and rhythm: you apply a controlled challenge, then give your body...
Cellular Energy and NAD in Healthy Aging: What Influences It (No Supplements)
We all feel the difference between an “on” day and a sluggish one. Underneath those swings lives your cell’s energy system: mitochondria—the tiny power...
Cellular Senescence Basics for Longevity: SASP, Stress, and Context
Aging cells do not simply fade into the background. Some stop dividing, change their shape, and begin broadcasting distress signals that affect nearby tissue....
Cold Acclimation Without the Shock: Gradual Approaches That Stick
Cold can sharpen attention within minutes and, over weeks, make your body better at producing its own heat. The key is dose: small, repeatable...
Cold Exposure for Healthy Aging: Benefits, Myths, and Safety
Cold is a simple, repeatable hormetic stressor: a small dose nudges your biology to adapt so you become more resilient. But “simple” does not...