GlyNAC for Aging: What Human Studies Suggest for Glutathione and Mitochondria
GlyNAC—the combination of glycine and N-acetylcysteine—aims to restore glutathione, the cell’s master antioxidant that declines with age. Over the last few years, small but...
Grape Seed Extract for Healthy Aging: OPCs and Vascular Health
Grape seed extract (GSE) concentrates a family of polyphenols called oligomeric proanthocyanidins (OPCs). Over the past two decades, human trials have explored whether standardized...
Hesperidin and Diosmin for Vascular Aging: Endothelial and Metabolic Support
Citrus bioflavonoids—especially hesperidin and diosmin—are among the best studied “venoactive” nutrients for blood vessel health. They originate in orange and lemon peels (hesperidin) and...
HMB for Aging: Muscle Preservation and Strength in Older Adults
Skeletal muscle is a powerful predictor of healthy aging. It shapes mobility, glucose control, resilience after illness, and independence. Among nutritional tools, β-hydroxy-β-methylbutyrate (HMB)—a...
Hyaluronic Acid for Skin Aging: Do Oral Supplements Work
Fine lines, dryness, and loss of bounce are visible signs of how the skin changes with age. Hyaluronic acid (HA)—a water-binding molecule found naturally...
Hydroxytyrosol for Longevity: Olive Polyphenols and Mediterranean Aging
Oral olive polyphenols have moved from culinary curiosity to serious candidates for healthy aging. Hydroxytyrosol—the best-studied phenolic from olives—appears to act at the crossroads...
Inositol for Healthy Aging: Insulin Sensitivity and Metabolic Support
Aging shifts how our cells handle glucose, lipids, and inflammation. Those shifts influence energy, sleep, body composition, and vascular health. Inositol—particularly the myo-inositol and...
Lutein and Zeaxanthin for Healthy Aging: Eye and Brain Support
Modern longevity is about protecting what lets you live well: clear vision, steady attention, and the ability to learn and adapt. Lutein and zeaxanthin—yellow...
Magnesium for Longevity: Sleep, Recovery, and Metabolic Health
Magnesium touches almost every system that shapes how well we age. It helps set our body clock, relaxes muscles after training, stabilizes blood sugar,...
Melatonin for Longevity: Sleep and Circadian Health in Aging
Melatonin is more than a sleep aid—it is a nightly time signal that helps the brain and body stay in sync. As we age,...
Microdose Lithium Orotate and Longevity: Evidence, Controversies, and Safety
Lithium has a long history in psychiatry at prescription doses, yet in recent years very low “microdose” supplements—most often as lithium orotate—have drawn attention...
NAC for Longevity: Oxidative Stress, Detox, and Resilience
N-acetylcysteine (NAC) has been used in hospitals for decades, yet its role in everyday health is less clear. As a precursor to glutathione—the cell’s...
NAD Plus in Aging: NR, NMN, Niacin, and Niacinamide Explained
Aging changes how our cells make and spend energy. Nicotinamide adenine dinucleotide (NAD) sits at the center of that story. NAD supports mitochondrial ATP...
NMN and NR for Longevity: Evidence, Use Cases, and Regulatory Status
Aging gradually lowers cellular NAD, a cofactor that powers energy metabolism and stress responses. Two vitamin B3–family precursors—nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR)—aim...
Omega 3s for Healthy Aging: EPA, DHA, and the Omega 3 Index
If you care about healthy aging, omega 3s are hard to ignore. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) build cell membranes, modulate inflammation,...
Phosphatidylserine for Cognitive Aging: Memory and Stress Regulation
Aging challenges the brain’s resilience long before disease is diagnosed. People notice slower recall, more mental fatigue, and a sharper stress response. Phosphatidylserine (PS)...